abstract：:Cancer pathologies are deeply associated with mitochondrial dysfunction. TFAM, transcription factor A of mitochondria plays eminent role in transcription and replication of mtDNA to synthesize different mitochondrial proteins, has been reported to have elevated levels during malignancy and can be a compelling target o...

journal_title：Medical hypotheses

authors： Pandey AK,Verma S

更新日期：2020-10-01 00:00:00

abstract：:Recently, a mini-review was published in the Medical Hypotheses journal by Usul Afsar entitled 2019-nCoV-SARS-CoV-2 (COVID-19) infection: Cruciality of Furin and relevance with cancer. Previous studies have pointed out that disruption of the proteolytic cleavage of proteins can promote infectious and non-infectious di...

journal_title：Medical hypotheses

authors： Drak Alsibai K

更新日期：2020-10-01 00:00:00

abstract：:Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabeti...

journal_title：Medical hypotheses

authors： Ozdemir F,Ari A,Kilcik MH,Hanbay D,Sahin I

更新日期：2020-10-01 00:00:00

abstract：:COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific ...

journal_title：Medical hypotheses

authors： Beyazit F,Beyazit Y,Tanoglu A,Haznedaroglu IC

更新日期：2020-10-01 00:00:00

abstract：:Treatment-resistant schizophrenia (TRS) is one of the subgroups of schizophrenia of which little is known with regard to its optimal mechanism. Treatment response, either as full remission of symptoms or prediction by biomarker, is important in psychiatry. We have proposed a model that integrates dopaminergic and glut...

journal_title：Medical hypotheses

authors： Huang LC,Lin SH,Tseng HH,Chen KC,Yang YK

更新日期：2020-10-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...

journal_title：Medical hypotheses

authors： Varadarajan S,Balaji TM,Sarode SC,Sarode GS,Sharma NK,Gondivkar S,Gadbail A,Patil S

更新日期：2020-10-01 00:00:00

abstract：:Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...

journal_title：Medical hypotheses

authors： Niv Y

更新日期：2020-10-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:It is a known fact that individuals who engaged in delinquent behavior in childhood are more probable to carry on similar behavior in adulthood. If the factors that lead children to involve in delinquency are defined, the risk of dragging children into crime can be detected before they are involved in crime and delinq...

journal_title：Medical hypotheses

authors： Ucuz I,Ciçek AU,Ari A,Ozcan OO,Aybüke Sari S

更新日期：2020-10-01 00:00:00

abstract：:COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells th...

journal_title：Medical hypotheses

authors： Pagliaro P

更新日期：2020-10-01 00:00:00

abstract：:Prepulse inhibition (PPI) of acoustic startle reflex is a measure of sensorimotor gating that may reflect the biological processes underlying gaiting impairments in schizophrenia. Although PPI is clinically useful, why PPI is inhibited in schizophrenia is largely unknown. Prepulse inhibition is mediated by M2-like mus...

journal_title：Medical hypotheses

authors： Sato K

更新日期：2020-10-01 00:00:00

abstract：:Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mo...

journal_title：Medical hypotheses

authors： Derwand R,Scholz M

更新日期：2020-09-01 00:00:00

abstract：:The cranial nerve rhizophathy, commonly presented with trigeminal neuralgia (TN) or hemifacial spasm (HFS), is a sort of hyperexcitability disorders with higher incidence in senior Asian. In this paper, a novel hypothesis on the pathogenesis is proposed and with which some clinical phenomena are explained. In those wi...

journal_title：Medical hypotheses

authors： Liu M,Zhong J

更新日期：2020-09-01 00:00:00

abstract：:The CoV-19 infection appears to be unusual among patients with type 1 Diabetes Mellitus, although they are considered a fragile population. We think that this in part due to the peculiar immune condition that leads to the destruction of the Beta cells. ...

journal_title：Medical hypotheses

authors： Tatti P,Tonolo G,Zanfardino A,Iafusco D

更新日期：2020-09-01 00:00:00

abstract：:The recent global pandemic created by the Coronavirus SARS-CoV-2, started in Wuhan, China in December 2019, has generated panic, both in term of human death (4-5% of infected patients identified through testing) and the global economy. Human sufferings seem to be continuing, and it is not clear how long this will cont...

journal_title：Medical hypotheses

authors： Ahmad SI

更新日期：2020-09-01 00:00:00

abstract：:The lymphatic system is an important component of human health and is critical in maintaining microcirculatory flow and immune system homeostasis. During septic shock, increased capillary permeability results in excess filtration of intravascular fluid and solutes producing interstitial edema with subsequent hydrostat...

journal_title：Medical hypotheses

authors： Pruitt LG

更新日期：2020-09-01 00:00:00

abstract：:Clinical trials designed to answer treatment-related questions typically compare an intervention group that receives a drug or other intervention to a control group that serves as a standard against which results of the intervention are evaluated. An observed divergence from this trend in research papers on breastfeed...

journal_title：Medical hypotheses

authors： Dimnjakovic J,Poljicanin T,Svajda M

更新日期：2020-08-01 00:00:00

abstract：:Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

journal_title：Medical hypotheses

authors： Zheng Z,Zhang Z,Wang M

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Results from a recent study showed that the risk of cardiovascular and all-cause mortality was higher in patients who received febuxostat, a potent urate-lowering agent, than that in patients who received allopurinol. Therefore, we hypothesized that an abrupt change in serum urate levels caused by urate-lowe...

journal_title：Medical hypotheses

authors： Lee JS,Oh JS,Kim YG,Lee CK,Yoo B,Hong S

更新日期：2020-08-01 00:00:00

abstract：:On March 11, 2020, the World Health Organization declared the coronavirus outbreak a pandemic. Since December 2019, the world has experienced an outbreak of coronavirus disease 2019 (COVID-19). Epidemiology, risk factors, and clinical characteristics of patients with COVID-19 have been reported but the factors affecti...

journal_title：Medical hypotheses

authors： Taghizadeh-Hesary F,Akbari H

更新日期：2020-07-01 00:00:00

abstract：:A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). Respiratory conditions are extensively described among more serious cases of COVID-19, and the onset of acute respiratory distress syndrome (ARDS) is one of the hallmark features of ...

journal_title：Medical hypotheses

authors： Geier MR,Geier DA

更新日期：2020-07-01 00:00:00

abstract：:The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent the spread of coronavirus. We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. It is demonstrated by docking models how amantadine can exert its action on Coronaviru...

journal_title：Medical hypotheses

authors： Abreu GEA,Aguilar MEH,Covarrubias DH,Durán FR

更新日期：2020-07-01 00:00:00

abstract：:The N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune encephalitis. Antibodies against the GluN1 subunit of the NMDAR showed in primary cultures of rat hippocampal neurons and in a mouse model pathogenic effects including cross-linking and internalization of the target receptors ...

journal_title：Medical hypotheses

authors： Ismail FS,Faustmann PM

更新日期：2020-06-01 00:00:00

abstract：:At present, researchers are still debating the effect of blue light on the eyes.Studies have shown thatwhile blue lighthelpsto maintain normal biological rhythms,excessive blue light radiation mayinduce fundus lesions. The preliminary survey shows that the incidence of vitreous floaters is high among digital device us...

journal_title：Medical hypotheses

authors： Chen JT,Wu HJ

更新日期：2020-06-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nuc...

journal_title：Medical hypotheses

authors： Koleva K,Pavlov O,Nikolov R,Behr R

更新日期：2020-06-01 00:00:00

abstract：:Novel coronavirus (NCoV-19), also known as SARS CoV-2, is a pathogen causing an emerging infection that rapidly increases in incidence and geographic range, is associated with the ever-increasing morbidity and mortality rates, and shows sever economic impact worldwide. The WHO declares the NCoV-19 infection disease (C...

journal_title：Medical hypotheses

authors： Mani Mishra P,Uversky VN,Nandi CK

更新日期：2020-04-24 00:00:00

abstract：:Retinopathy of prematurity (ROP) is a disease of the immature retina and is the leading global cause of blindness in children. Two postnatal phases of the disease are distinguished, the first phase is thought to be caused by hyperoxia. One of the most relevant ROP risk factor in routine clinical practice is blood tran...

journal_title：Medical hypotheses

authors： Podraza W

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Pregnancy is characterized by multiple metabolic processes to allow proper foetal development and ensure adequate stores. Little is known about the interactions between maternal and foetal metabolism during the last phase of pregnancy. Metabolomic offers potential to discover changes in maternal metabolism i...

journal_title：Medical hypotheses

authors： Perrone S,Laschi E,De Bernardo G,Giordano M,Vanacore F,Tassini M,Calderisi M,Toni AL,Buonocore G,Longini M

更新日期：2020-04-01 00:00:00

abstract：:There is no secret that despite the rapid development of new methods of cancer therapy, we still are not able to completely destroy the tumor. Every time we attack the tumor, the tumor neutralizes our attempts. Carcinogenesis can be presented as a tree whose branches are different pro-tumor mechanisms and whose trunk ...

journal_title：Medical hypotheses

authors： Malyshev IY,Kuznetsova LV,Mardente S

更新日期：2020-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) is defined as elevated mean pulmonary artery pressure secondary to e.g. congenital heart disease and chronic obstructive pulmonary disease. It elevates right ventricular afterload that eventually leads to cor pulmonale and right heart failure. Experimental research has shown that cardioprot...

journal_title：Medical hypotheses

authors： Maarman GJ

更新日期：2020-04-01 00:00:00

abstract：:Increased level of oxalates in urine and plasma can be attributed to endogenous overproduction, increased ingestion or excessive intestinal absorption. When a supersaturation status is reached, oxalates combine with calcium and crystallize to form 80% of the urinary stones. Several cardiovascular diseases such as coro...

journal_title：Medical hypotheses

authors： Arafa A,Eshak ES,Iso H

更新日期：2020-04-01 00:00:00

abstract：:Therapies for preventing reperfusion injury (RI) have been widely studied. However, the attempts to transfer cardioprotective therapies for reducing RI from experiments into clinical practice have been so far unsuccessful. Pathophysiological mechanisms of RI are complicated and compose of many pathways e.g. hypercontr...

journal_title：Medical hypotheses

authors： Barzyc A,Łysik W,Słyk J,Kuszewski M,Zarębiński M,Wojciechowska M,Cudnoch-Jędrzejewska A

更新日期：2020-04-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) and Duchenne muscular dystrophy (DMD) are two deadly neuromuscular degenerative diseases of childhood. Knowledge on their pathophysiological mechanisms may direct us towards treatment or a cure. Although these diseases are caused by two totally different gene-mutations and cause ...

journal_title：Medical hypotheses

authors： Offringa-Hup A

更新日期：2020-04-01 00:00:00

abstract：:The origin and initiating features of PBC remain obscure despite decades of study. However, recent papers have demonstrated loss of canals of Hering (CoH) to be the earliest histologic change in liver biopsy specimens from patients with primary biliary cholangitis (PBC). We posit that CoH loss prior to significant inf...

journal_title：Medical hypotheses

authors： Theise ND,Crawford JM,Nakanuma Y,Quaglia A

更新日期：2020-03-16 00:00:00

abstract：:Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson dis...

journal_title：Medical hypotheses

authors： Polat K,Nour M

更新日期：2020-03-16 00:00:00

abstract：:Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for t...

journal_title：Medical hypotheses

authors： Deng J,Wang M,Guo Y,Fischer H,Yu X,Kem D,Li H

更新日期：2020-03-14 00:00:00

abstract：:Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...

journal_title：Medical hypotheses

authors： Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman E

更新日期：2020-03-01 00:00:00

abstract：:We tested the hypothesis that if SPECT/CT-detected volumes of active and inactive parts of brain tissue present correlation with the results of hyperbaric oxygen therapy (HBOT) of ischemic stroke, SPECT imaging may serve as a selective tool for post-stroke patients to indicate cases that may significantly benefit from...

journal_title：Medical hypotheses

authors： Golan H,Makogon B,Volkov O,Smolyakov Y,Hadanny A,Efrati S

更新日期：2020-03-01 00:00:00

abstract：:In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a ch...

journal_title：Medical hypotheses

authors： Pavlov O,Mirchev N,Behr R

更新日期：2020-02-21 00:00:00